SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME MANNICH BASES DERIVED FROM ISATIN ISONICOTINIC ACID HYDRAZONE
نویسندگان
چکیده
منابع مشابه
Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH).
N'-(1-alkyl-2,3-dihydro-2-oxo-1H-3-indolyliden)-4-pyridinecarboxylic acid hydrazide derivatives, 3(a-g), were synthesized in a trial to overcome the resistance developed with the therapeutic uses of isoniazid (INH). The lipophilicity of the synthesized derivatives supersedes that of the INH as expressed by Clog p values. The synthesized compounds and INH were tested against bovin, human sensiti...
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15 صفحه اولPanda: Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases
In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The NMannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemica...
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Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...
متن کاملSynthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide
Two new Schiff and Mannich bases, namely, 1-Morpholinomethyl-3(1' -N-dithiooxamide)iminoisatin (L(I)H) and 1-diphenylaminomethyl-3-1'-N-dithiooxamide)iminoisatin (L(II)H), were prepared from condensation reaction of new Schiff base 3-(1'-N-dithiooxamide)iminoisatin (SBH) with morpholine or diphenylamine respectively in presence of formaldehyde . The structures were characterized by IR, (1)HNMR,...
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ژورنال
عنوان ژورنال: Bulletin of Pharmaceutical Sciences. Assiut
سال: 2005
ISSN: 1110-0052
DOI: 10.21608/bfsa.2005.65240